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云南兔儿风的五环三萜类化学成分研究(PDF)

《广西植物》[ISSN:1000-3142/CN:45-1134/Q]

期数:
2015年01期
页码:
109-114
栏目:
植物化学与化学生物学
出版日期:
2015-03-27

文章信息/Info

Title:
The pentacyclic triterpene of Ainsliaea yunnanensis
文章编号:
1000-3142(2015)01-0109-06
作者:
吴相雷12 熊筱娟1 吴志军2 沈云亨3 黄 皓1*
1. 宜春学院 化学与生物工程学院, 江西 宜春 336000; 2. 中国人民解放军第二军医大学 长征医院, 上海 200003; 3. 中国人民解放军第二军医大学 药学院, 上海 200433
Author(s):
WU Xiang-Lei12 XIONG Xiao-Juan1 WU Zhi-Jun2 SHEN Yun-Heng3 HUANG Hao1*
1. College of Chemical and Biological Engineering, Yichun University, Yichun 336000, China; 2. Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; 3. College of Pharmacy, Second Military Medical University, Shanghai 200433, China
关键词:
云南兔儿风 化学成分 五环三萜
Keywords:
Ainsliaea yunnanensis chemical constituents pentacyclic triterpene
分类号:
Q946.8
DOI:
10.11931/guihaia.gxzw201404039
文献标识码:
A
摘要:
以采自云南省楚雄自治州楚雄市的云南兔儿风(Ainsliaea yunnanensis)干燥地上部分为研究对象,应用现代色谱手段(硅胶柱色谱、ODS柱色谱、Sephadex LH-20凝胶柱色谱、制备液相及制备薄层色谱等),从云南兔儿风植物中分离单体化合物,运用光谱分析技术(MS、1H-NMR、13C-NMR、DEPT、COSY、HSQC、HMBC、ROSEY)鉴定其化学结构,对云南兔儿风的化学成分进行研究,为兔儿风属植物研究及植物开发利用提供一定的物质基础。结果表明:从云南兔儿风乙醇提取物中共分离得到了11个五环三萜类化合物,分别鉴定为α-香树脂醇乙酸酯(1)、羽扇豆醇乙酸酯(2)、9,12-二烯乌苏烷乙酸酯(3)、α-香树脂酮(4)、羽扇豆烯酮(5)、蛇菰素B(6)、降香萜醇乙酸酯(7)、齐墩果烷-11-羰基-12-烯-3-醇棕榈酸酯(8)、12-烯基白桦脂醇(9)、西米杜鹃醇(10)、二十烷酸羽扇豆醇乙酸酯(11)。其中,化合物1~6,9~11均为首次从该植物中分离得到。通过对云南兔儿风化学分进行深入研究,明确其主要的活性成分,阐明云南兔儿风药用植物中抗炎活性物质基础,为相关的新药科研工作及产品开发提供重要的科学依据。
Abstract:
Plants of Asteraceae are well known for containing biologically active chemical constituents. Within this family,the genus Ainsliaea comprises 70 species,48 of which are indigenous to China. Many Ainsliaea species are used in Chinese folk medicine for various indications. A. yunnanensis,Ainsliaea compositae plant,is born in 1 700-2 700 m above sea level of forests,forest margins,or mountain grass,mainly distributed in Yunnan,Sichuan and other places. And it is used in clinic to treat injuries,fractures,rheumatism bones and muscles pain,indigestion,sores and insect product disease. The latest pharmcological research revealed that A. yunnanensis had wide range of biological activities,such as antioxidant,antitumor,antiinflammatory properties. To explore the material basis of antiinflammatory activities and establish the basis for exploitation and utilization for the future,we had conducted a phytochemical investigation on the EtOH extract of the aerial parts of A. yunnanensis. So far,several sesquiterpenes,triterpenes and flavonoids,had been isolated from this genus. For example,arbutin,friedelin,friedelan-3β-ol,fernenol fom A. frans Champ. 8-α-hydroxy-11α,13-dihydrozaluzanin C,3-O-β-D-glucozaluzanin C from A. fragrans Champ. Acaciin,luteolin,luteolin-7-O-β-D-glucoside,chrysoeriol-7-O-β-D-glucoside,apigenin-7-O-β-D-glucoside from A. bonatii Beauverd. 3,5-dicaffeoylquinic acid and 4,5-dicaffeoylquinic acid from Ainsliaea fragrans Champ. Ainsliaea A,ainsliaea B,zaluzanin C,3-O-(9Z,12Z,15Z-octadecatrienoy1)glycerol,3-0-(9Z,2Z-octadecatrienoy1)glycerol and glueozaluzanin C from A. acerifolia SchBip and A. dissecta Franch Et Sav. Ainsliolide A,ainsliolide B,taraxinc acid,taraxinic acid-14-O-β-D-glueopyranoside from Ainsliaea acerifolia vat subapoda. Three dimeric sesquiterpene lactones were identified as ainsliadimer A,ainsliadimer B,ainsliadimer C from A. macrocephal,and one dimeric sesquiterpene lactone was identified as gochnatiolide A from A. henryi,two triple sesquiterpene lactones(ainsliatriimer A,ainsliatrimer B)from A. fulvioides. In the dissertation,we investigated the chemical constitients of A. yunnanensis systematically,the plant material was collected in Chuxiong Yi Autonomous Prefecture,Yunnan Province,China and identified by Prof. Tan Ceming,plant herbarium of Jiangxi Province. Eleven pentacyclic triterpene compounds were isolated and identified as α-amyrin acetate(1),lupenyl acetate(2),3β-acetoxy-9(11):12-diene-ursan(3),α-amyrenone(4),lupenone(5),balanophorin B(6),bauerenyl acetate(7),3β-hydroxy-11-oxo-olean-12-enyl palmitate(8),lupa-12,20(29)-dien-3β,28-diol(9),simiarenol(10),lup-20(29)-ene-3β-yl eicosanoate(11). These compounds were isolated from A. yunnanensis by silica gel,ODS,Sephadex LH-20,preparative HPLC and preparative TLC and were identified by spectral analysis(MS,1H-NMR,13C-NMR,DEPT,COSY,HSQC,HMBC,ROSEY). Compounds 1-6,9-11 were isolated from A. yunnanensis for the first time. The genus Ainsliaea has been commonly used as crude material of traditional Chinese medicine for a long time,but the study of the genus was sparse,therefore this study would accumulat data for chemical constituents research of the genus.

参考文献/References

Chen SH(陈书红),Yang JS(杨峻山),Ren FZ(任风芝),et al. 2006. Periploca sepium Bunge antitumor active ingredient research(香加皮的抗肿瘤活性成分研究)[J]. Chin Trad & Herb Drug(中草药),37(4):519-520
Dai Z(戴忠),Wang GL(王钢力),Wang F(王峰),et al. 2005. Chemical contituents of Balanophora simaoensis(思茅蛇菰的化学成分研究)(I)[J]. Chin Trad & Herb Drug(中草药),36(6):830-831
Editorial Commitee(中国科学院中国植物志编辑委员会). 1996. Flora of China(中国植物志)[M]. Beijing:Science Press(科学出版社)
Guo LJ(郭良君),Tan XQ(谭兴起),Zheng W(郑巍),et al. 2011. Chemical contituents of Ficus tikoua(地瓜藤化学成分研究)[J]. Chin Trad & Herb Drug(中草药),42(9):1 709-1 711
Hideyuki T,Hiroyuki K,Tatsuharu T,et al. 2001. Hipeol esters from the twig bark of Japanese pear(Pyrus serotinaRehd. )[J]. Biosci Biotechnol Biochem,65(5):1 198-1 201
Jia L(贾靓),Min ZD(闵知大),2005. Chemical contituents of Daphne odora Thunb. var. atrocaulis. Rehd.(毛瑞香化学成分的研究)[J]. Chin Trad & Herb Drug(中草药),36(9):1 311-1 312
Jiangsu New Medical College(江苏新医学院). 1977. Dictionary Traditional Drugs(中药大辞典)[M]. Shanghai:Shanghai People’s Publishing House(上海人民出版社)
Liu JL(刘金磊),Pan ZH(潘争红),Su T(苏涛),et al. 2012. Chemical constituents from twigs and leaves of Fordia cauliflora(壮药干花豆枝叶化学成分研究)[J]. Chin Trad & Herb Drug(中草药),43(6):1 071-1 074
Marizeth LB,Jorge MD,Pedro APP,et al. 2002. Fatty acid esters of triterpenes from Erythroxylum passerinum[J]. J Braz Chem Soc,13(5):669-673
Nguyen VT,Nguyen VH,Le MH. 2002. Antimalarial principles of ficus fistulosa[J]. J Chem,40(4):75-78
Rosa MPG. 2005. Pentacyclic triterpenes from Cirsium Pascuarense[J]. J Chil Chem Soc,50(3):587-589
Tian L(田亮). 2004. The chemical constituents from the Hemiphragma heterophyllum Wall(鞭打绣球及云南兔耳风的化学成分研究)[D]. Beijing:Peking Union Medical College(中国协和医科大学):34-38
Wang R(王蓉),Sun Z(孙珍),Wang AL(王阿利),et al. 2013. GC-MS analysis of low polar components from Ainsliaea yunnanensis(云南兔儿风小极性成分GC-MS分析)[J]. J Chin Med Mat(中药材),36(1):61-64
Wen J(温晶),Shi HM(史海明),Tu PF(屠鹏飞),et al. 2010. Chemical contituents of Artemisia amomala(刘寄奴的化学成分研究)[J]. Chin Trad & Herb Drug(中草药),41(6):870-873
Zhao KJ(赵奎君),Liu SL(刘锁兰),Yang J(杨隽),et al. 2001. Studies on chemical contituents of Adenophora wawreana(多歧沙参化学成分的研究)[J]. Chin Trad & Herb Drug(中草药),32(11):964-966

备注/Memo

备注/Memo:
收稿日期: 2014-05-16修回日期: 2014-12-19
基金项目: 国家“重大新药创制”科技重大专项(2009ZX09502-013); 2013年江西省学位与研究生教育教学改革研究项目(JXYJG-2013-112)。
作者简介: 吴相雷(1988-),女,河南新蔡县人,硕士研究生,主要从事天然产物化学研究,(E-mail)332954266@qq.com。 *通讯作者: 黄皓,教授,硕士生导师,研究方向为药用植物成分与抗肿瘤药物开发,(E-mail)jxychh2008@163.com。
更新日期/Last Update: 2015-03-08