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罗汉果根多糖的分离纯化、结构鉴定及抗肿瘤活性研究

《广西植物》[ISSN:1000-3142/CN:45-1134/Q]

期数:
2012年01期
页码:
138
栏目:
植物化学与化学生物学
出版日期:
2012-01-25

文章信息/Info

Title:
Studies on isolation、purification、structural identification and its antitumor activity of polysaccharides from Momordica grosvenori swingle’s root
作者:
颜小捷12 卢凤来1 陈换莹12 李典鹏1*
1.广西植物功能物质研究与利用重点实验室 (广西植物研究所), 广西 桂林 541006; 2.广西师范大学 生命科学学院, 广西 桂林 541004
Author(s):
YAN XiaoJie12 LU FengLai1 CHEN HuanYing12 LI DianPeng1*
1.Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guilin 541006, China; 2.College of life science, Guangxi Normal University, Guilin 541004, China
关键词:
罗汉果根 多糖 分离纯化 单糖组成分析 抗肿瘤
Keywords:
Momordica grosvenori swingle’s root polysaccharides isolation and purification structural identification antitumor
分类号:
Q539
DOI:
-
文献标识码:
A
摘要:
: 采用水提醇沉法提取、DEAE52纤维素柱粗分离罗汉果根粗多糖(CPS),纸层析结合高效液相色谱分析CPS的单糖组成;同时研究CPS对小鼠H22皮下种植性肿瘤的影响。结果表明:采用DEAE52纤维素柱粗分离得到5个多糖组分;CPS的单糖组成为:葡萄糖、阿拉伯糖、木糖,其中以葡萄糖为主;与模型对照组比较,CPS各剂量组无明显的抑制肿瘤生长作用(抑瘤率均低于50%);与模型对照组比较,CPS各剂量组小鼠的胸腺指数显著提高,差异极显著(P<0.01);而脾脏指数显著降低,差异极显著(P<0.01)。
Abstract:
Polysaccharide(CPS)of Momordica grosvenori swingle’s roots was extracted by water extractingalcohol precipitating method,and then was pufified by DEAE52 cellulose. Their compositions were analyzed by paper chromatography and high performance liquid chromatography(HPLC). And the effect of CPS on H22 subcutaneous planting of mice was studied. Results:CPS was isolated into five fractionates by DEAE52 cellulose column chromatography,its simple sugars composition included glucose,arabillose and xylose. Compared with model group,each dose group had no significant functions in suppressing tumor growth(inhibition rate<50%);Besides,Compared with model group,each dose group had improved influence on the index of thymus(P<0.01),but had reduced influence on the index of spleen(P<001).

参考文献/References

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2012-01-25